Mutations Analysis of the Growth Differentiation Factor 9 Gene in Syrian Women with Ovarian Failure
نویسندگان
چکیده
منابع مشابه
Simultaneous Presence of G1 and G4 Mutations in Growth Differentiation Factor 9 Gene of Iranian Sheep
The fecundity in sheep has been much interested for producers due to its economical importance. Growth differentiation factor 9 (GDF9) is an autosomal gene with over dominance effect for twosingle nucleotide polymorphisms(SNPs), which resulted in sterility in homozygote mutant ewes and additive effect for three SNPs, without showing sterility event. In the present study, DNA was extracted from ...
متن کاملMutational screening of the coding region of growth differentiation factor 9 gene in Indian women with ovarian failure.
OBJECTIVE To establish the risk associated with mutations in the coding region of GDF9 gene in Indian women with ovarian failure. DESIGN This case-control study was designed for mutational analysis of the GDF9 coding region in a cohort of women with premature ovarian failure (n = 127), primary amenorrhea (n = 58), and secondary amenorrhea (n = 10) compared with controls (n = 220). RESULTS T...
متن کاملP-125: Identification of Novel Missense Mutations of The TGFBR3 Gene in Chinese Women with Premature Ovarian Failure
Background The aim of this study was to assess the ssociation between human transforming growth factor b receptor,type III (TGFBR3) and idiopathic premature ovarian failure (POF) in a Chinese population. MaterialsAndMethods A total of 112 Chinese women with idiopathic POF and 110 normal controls were examined. DNA samples prepared from blood leukocytes were used as templates for polymerase-chai...
متن کاملsimultaneous presence of g1 and g4 mutations in growth differentiation factor 9 gene of iranian sheep
the fecundity in sheep has been much interested for producers due to its economical importance. growth differentiation factor 9 (gdf9) is an autosomal gene with over dominance effect for twosingle nucleotide polymorphisms(snps), which resulted in sterility in homozygote mutant ewes and additive effect for three snps, without showing sterility event. in the present study, dna was extracted from ...
متن کاملScreening for FecGH Mutation of Growth Differentiation Factor 9 Gene in Iranian Ghezel Sheep Population
Background Ghezel sheep are highly prolific and one of the local sheep breeds in Iran and Turkey. Growth differentiation factor-9 (GDF9) gene has been found to be essential for growth and differentiation of early ovarian follicles. Novel mutations in GDF9 have been associated with increased ovulation rates and high litter sizes in heterozygous carriers. Therefore, fecundity gene for GDF9 (FecGH...
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ژورنال
عنوان ژورنال: INTERNATIONAL JOURNAL OF HUMAN GENETICS
سال: 2015
ISSN: 0972-3757,2456-6330
DOI: 10.31901/24566330.2015/15.03.05